Ecological developmental biology : integrating epigenetics, medicine, and evolution / Scott F. Gilbert, David Epel.
Material type: TextPublisher: Sunderland, Mass. : Sinauer, 2009Description: xv,480 p,. figures,tables,maps,diagramsISBN: 9780878932993 (paperbound); 0878932992 (paperbound)Subject(s): Phenotypic plasticity | Developmental biology | Epigenesis | Evolution (Biology) | Adaptation, Biological -- genetics | Endocrine Disruptors -- adverse effects | Environmental Pollution -- adverse effects | Epigenesis, Genetic | Gene Expression Regulation, Developmental -- physiology | TeratogensDDC classification: 574.52 LOC classification: QH438.5 | G55 2009QH438.5 | .G55 2009Summary: When the molecular processes of epigenetics meet the ecological processes of phenotypic plasticity, the result is a revolutionary new field: ecological developmental biology, or "eco-devo." This new science studies development in the "real world" of predators, pathogens, competitors, symbionts, toxic compounds, temperature changes, and nutritional differences. These environmental agents can result in changes to an individual's phenotype, often implemented when signals from the environment elicit epigenetic changes in gene expression. Ecological developmental biology is a truly integrative biology, detailing the interactions between developing organisms and their environmental contexts. Ecological developmental biology also provides a systems approach to the study of pathology, integrating the studies of diabetes, cancers, obesity, and the aging syndrome into the framework of an ecologically sensitive developmental biology. It looks at examples where the environment provides expected cues for normal development and where the organism develops improperly without such cues. Data from research on teratology, endocrine disruptors, and microbial symbioses, when integrated into a developmental context, may have enormous implications for human health as well as the overall health of Earth's ecosystems. The study of epigenetics--changes in gene expression that are not the result of changes in a gene's DNA sequence--has recently provided startling insights not only into mechanisms of development, but also into the mechanisms and processes of evolution. The notion that epialleles (changes in chromosome structure that alter gene expression) can be induced by environmental agents and transmitted across generations has altered our notions of evolution, as have new experiments documenting the genetic fixation of environmentally induced changes in development. The widespread use of symbiosis in development provides new targets for natural selection. Ecological developm.Item type | Current location | Call number | Status | Date due | Barcode |
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Books | GKVK Library | 574.52 GIL (Browse shelf) | Available | 135831 |
PART I: ENVIRONMENTAL SIGNALS AND NORMAL DEVELOPMENT The Environment as a Normal Agent in Producing Phenotypes How Agents in the Environment Effect Molecular Changes in Development Developmental Symbiosis: Co-Development as a Strategy for Life Embryonic Defenses: Survival in a Hostile World PART II: ECOLOGICAL DEVELOPMENTAL BIOLOGY AND DISEASE STATES Teratogenesis: Environmental Assaults on Development Endocrine Disruptors The Epigenetic Origin of Adult Diseases PART III: TOWARD A DEVELOPMENTAL EVOLUTIONARY SYNTHESIS The Modern Synthesis: Natural Selection of Allelic Variation Evolution through Developmental Regulatory Genes Environment, Development, and Evolution: Toward a New Synthesis CODA: Philosophical Concerns Raised by Ecological Developmental Biology APPENDX A: Lysenko, Kammerer, and the Truncated Tradition of Ecological Developmental Biology APPENDIX B: The Molecular Mechanisms of Epigenetic Change APPENDIX C: Writing Development Out of the Modern Synthesis APPENDIX D: Epigenetic Inheritance Systems: The Inheritance of Environmentally Induced Traits.
When the molecular processes of epigenetics meet the ecological processes of phenotypic plasticity, the result is a revolutionary new field: ecological developmental biology, or "eco-devo." This new science studies development in the "real world" of predators, pathogens, competitors, symbionts, toxic compounds, temperature changes, and nutritional differences. These environmental agents can result in changes to an individual's phenotype, often implemented when signals from the environment elicit epigenetic changes in gene expression. Ecological developmental biology is a truly integrative biology, detailing the interactions between developing organisms and their environmental contexts. Ecological developmental biology also provides a systems approach to the study of pathology, integrating the studies of diabetes, cancers, obesity, and the aging syndrome into the framework of an ecologically sensitive developmental biology. It looks at examples where the environment provides expected cues for normal development and where the organism develops improperly without such cues. Data from research on teratology, endocrine disruptors, and microbial symbioses, when integrated into a developmental context, may have enormous implications for human health as well as the overall health of Earth's ecosystems. The study of epigenetics--changes in gene expression that are not the result of changes in a gene's DNA sequence--has recently provided startling insights not only into mechanisms of development, but also into the mechanisms and processes of evolution. The notion that epialleles (changes in chromosome structure that alter gene expression) can be induced by environmental agents and transmitted across generations has altered our notions of evolution, as have new experiments documenting the genetic fixation of environmentally induced changes in development. The widespread use of symbiosis in development provides new targets for natural selection. Ecological developm.
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